Strata-bound Cu- (Ag) deposits, long known as 'Chilean manto-type', occur along the Coastal Cordillera of northern Chile (22°-30°S) hosted by Jurassic and Lower Cretaceous volcanic and volcano-sedimentary rocks. These deposits are typical of the first stage of Andean evolution characterised by an extensional setting of the arc magmatism along the active margin of South America. Strata-bound Cu- (Ag) deposits were formed during two metallogenic epochs in the Late Jurassic and uppermost Early Cretaceous. The mineralisation took place at the time of structurally controlled emplacement of batholiths within the Mesozoic volcanic and sedimentary strata. The volcanic-hosted strata-bound Cu- (Ag) deposits invariably occur distal, but peripheral to coeval batholiths emplaced within tilted Mesozoic strata. The prevalent view that these deposits have an inherent genetic relationship with hydrothermal fluid derivation from subvolcanic stocks and dykes is contended here, because these minor intrusions are largely barren and this hypothesis does not fit well with Sr, Os and Pb isotopic data that call for crustal contribution of these elements. The strata-bound Cu- (Ag) mineralisation appears to be produced by fluids of mixed origin that were mobilised within penneable levels and structural weakness zones of the Mesozoic arc-related volcano-sedimentary sequence during the emplacement of shallow granodioritic batholiths under transtensional regimes. These hydrothermal fluids deposited copper and subordinate silver when reacted with organic matter, pyrite and/or cooled away from their heat sources. Although strata-bound Cu- (Ag) mineralisation took place during the same Cretaceous metallogenic event that formed the magnetite-apatite bodies, and Fe-oxide-Cu-Au deposits along the present Coastal Cordillera, the conceivable relationships with these other types of deposits are hampered by the inconclusive debate about the origin of the Chilean Fe-oxide deposits. However, the available data strongly suggest that the Fe oxide-rich deposits are metasomatic in origin and genetically related to contact zones of Lower Cretaceous dioritic batholiths, whereas the iron-poor volcanic-hosted Cu-(Ag) stratabound deposits constitute distal mineralisation peripheral to Upper Jurassic of Lower Cretaceous granodioritic batholiths.